Volume 3, Issue 3, May 2015, Page: 39-51
Kinetic Parameters Survey for Manufacture of Pralidoxime
Daniel Antonio Shimizu Kitagawa, Division of Chemical, Biological and Nuclear Defense, Technological Centre of Army, CTEx, Rio de Janeiro, Brazil
Sabrina Teixeira Martinez, Chemical Engineering Department, Military Institute of Engineering, IME, Rio de Janeiro, Brazil; Organic Chemistry Department, Chemical Institute, Federal University of Rio de Janeiro, UFRJ, Rio de Janeiro, Brazil
Erick Braga Ferrao Galante, Chemical Engineering Department, Military Institute of Engineering, IME, Rio de Janeiro, Brazil
Tanos Celmar Costa Franca, Chemical Engineering Department, Military Institute of Engineering, IME, Rio de Janeiro, Brazil; Center for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Kralove, Hradec Kralove, Czech Republic
Received: Jun. 18, 2015;       Accepted: Jun. 29, 2015;       Published: Jul. 14, 2015
DOI: 10.11648/j.ajche.20150303.12      View  4099      Downloads  110
Abstract
Chemical agents represent a serious threat to the modern world. Among them, they stand out nerve agents because of its high lethality and dangerousness. They are typically organophosphate compounds, which act by inhibiting acetylcholinesterase, a key enzyme in the transmission of nerve impulses process. There are several forms of treatment for organophosphate poisoning, and pralidoxime (2-PAM) is the drug most used as reactivator of acetylcholinesterase. In this work, we developed the first three steps for the synthesis of 2-PAM, with the objective of obtaining data to calculate the kinetic parameters of these steps. These parameters may be used for the manufacture of 2-PAM in semi-pilot scale. Through the studies conducted it has been found that the preparation of the oxime has very rapid kinetics.
Keywords
Chemicals warfare agents, Organophosphates compounds, Acetylcholinesterase, Oximes, Pralidoxime
To cite this article
Daniel Antonio Shimizu Kitagawa, Sabrina Teixeira Martinez, Erick Braga Ferrao Galante, Tanos Celmar Costa Franca, Kinetic Parameters Survey for Manufacture of Pralidoxime, American Journal of Chemical Engineering. Vol. 3, No. 3, 2015, pp. 39-51. doi: 10.11648/j.ajche.20150303.12
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