Synthesis and Pharmacokinetic Evaluation of Novel Bioactive Organic Compounds

Bienvenu Glinma; Sedami Medegan Fagla; Hyacinthe Finagnon Agnimonhan; Benedicta Kpadonou-Kpoviessi; Eleonore Yayi; Joachim Gbenou; Jacques Poupaert; Fernand Gbaguidi; Salome Kpoviessi

doi:doi:10.11648/j.ajche.20261401.11

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Synthesis and Pharmacokinetic Evaluation of Novel Bioactive Organic Compounds

Bienvenu Glinma^*

, Sedami Medegan Fagla

, Hyacinthe Finagnon Agnimonhan

, Benedicta Kpadonou-Kpoviessi

, Eleonore Yayi, Joachim Gbenou, Jacques Poupaert, Fernand Gbaguidi

, Salome Kpoviessi

Published in American Journal of Chemical Engineering (Volume 14, Issue 1)

Received: 24 November 2025 Accepted: 22 January 2026 Published: 26 January 2026

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Abstract

The integration of medicinal chemistry with modern computational and in silico approaches enables the scientific re-evaluation of traditional knowledge, particularly highlighting the role of organic bioactives products. This study describes the synthesis and pharmacokinetic profiling of a series of organic compounds of pharmaceutical interest that were designed to act as potential bioactive agents. Synthesis strategies were optimized to improve reaction yields. Comprehensive spectroscopic analyses, including nuclear magnetic resonance analysis of protons and carbon-13 (¹H and ¹³C) and mass spectrometry, were employed to verify the molecular structures and evaluate the purity of the synthesized compounds. The synthesized products were then theoretically evaluated for their pharmacokinetics using standard drug-type tests. The results revealed that products were obtained in the best yields (65-82%) using our validated protocols of synthesis and characterized for their structure. For the theoretical study on their pharmaceuticals assessments, most of the compounds exhibited favorable pharmacokinetic profiles (that satisfied the key criteria of Lipinski, and the Connolly parameters (solubility and stability)), as well as demonstrating a good safety profile. This study highlights the importance of combining optimized synthesis methodologies with computational pharmacokinetic screening as an effective method for the initial design and evaluation of new molecules.

Published in	American Journal of Chemical Engineering (Volume 14, Issue 1)
DOI	10.11648/j.ajche.20261401.11
Page(s)	1-7
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2026. Published by Science Publishing Group

Keywords

Synthesis, Spectroscopic Characterization, In Silico Pharmacokinetics, Lipinski-compliant Drug-likeness

References

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APA Style

Glinma, B., Fagla, S. M., Agnimonhan, H. F., Kpadonou-Kpoviessi, B., Yayi, E., et al. (2026). Synthesis and Pharmacokinetic Evaluation of Novel Bioactive Organic Compounds. American Journal of Chemical Engineering, 14(1), 1-7. https://doi.org/10.11648/j.ajche.20261401.11

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ACS Style

Glinma, B.; Fagla, S. M.; Agnimonhan, H. F.; Kpadonou-Kpoviessi, B.; Yayi, E., et al. Synthesis and Pharmacokinetic Evaluation of Novel Bioactive Organic Compounds. Am. J. Chem. Eng. 2026, 14(1), 1-7. doi: 10.11648/j.ajche.20261401.11

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AMA Style

Glinma B, Fagla SM, Agnimonhan HF, Kpadonou-Kpoviessi B, Yayi E, et al. Synthesis and Pharmacokinetic Evaluation of Novel Bioactive Organic Compounds. Am J Chem Eng. 2026;14(1):1-7. doi: 10.11648/j.ajche.20261401.11

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@article{10.11648/j.ajche.20261401.11,
  author = {Bienvenu Glinma and Sedami Medegan Fagla and Hyacinthe Finagnon Agnimonhan and Benedicta Kpadonou-Kpoviessi and Eleonore Yayi and Joachim Gbenou and Jacques Poupaert and Fernand Gbaguidi and Salome Kpoviessi},
  title = {Synthesis and Pharmacokinetic Evaluation of Novel Bioactive Organic Compounds},
  journal = {American Journal of Chemical Engineering},
  volume = {14},
  number = {1},
  pages = {1-7},
  doi = {10.11648/j.ajche.20261401.11},
  url = {https://doi.org/10.11648/j.ajche.20261401.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajche.20261401.11},
  abstract = {The integration of medicinal chemistry with modern computational and in silico approaches enables the scientific re-evaluation of traditional knowledge, particularly highlighting the role of organic bioactives products. This study describes the synthesis and pharmacokinetic profiling of a series of organic compounds of pharmaceutical interest that were designed to act as potential bioactive agents. Synthesis strategies were optimized to improve reaction yields. Comprehensive spectroscopic analyses, including nuclear magnetic resonance analysis of protons and carbon-13 (¹H and ¹³C) and mass spectrometry, were employed to verify the molecular structures and evaluate the purity of the synthesized compounds. The synthesized products were then theoretically evaluated for their pharmacokinetics using standard drug-type tests. The results revealed that products were obtained in the best yields (65-82%) using our validated protocols of synthesis and characterized for their structure. For the theoretical study on their pharmaceuticals assessments, most of the compounds exhibited favorable pharmacokinetic profiles (that satisfied the key criteria of Lipinski, and the Connolly parameters (solubility and stability)), as well as demonstrating a good safety profile. This study highlights the importance of combining optimized synthesis methodologies with computational pharmacokinetic screening as an effective method for the initial design and evaluation of new molecules.},
 year = {2026}
}

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TY  - JOUR
T1  - Synthesis and Pharmacokinetic Evaluation of Novel Bioactive Organic Compounds
AU  - Bienvenu Glinma
AU  - Sedami Medegan Fagla
AU  - Hyacinthe Finagnon Agnimonhan
AU  - Benedicta Kpadonou-Kpoviessi
AU  - Eleonore Yayi
AU  - Joachim Gbenou
AU  - Jacques Poupaert
AU  - Fernand Gbaguidi
AU  - Salome Kpoviessi
Y1  - 2026/01/26
PY  - 2026
N1  - https://doi.org/10.11648/j.ajche.20261401.11
DO  - 10.11648/j.ajche.20261401.11
T2  - American Journal of Chemical Engineering
JF  - American Journal of Chemical Engineering
JO  - American Journal of Chemical Engineering
SP  - 1
EP  - 7
PB  - Science Publishing Group
SN  - 2330-8613
UR  - https://doi.org/10.11648/j.ajche.20261401.11
AB  - The integration of medicinal chemistry with modern computational and in silico approaches enables the scientific re-evaluation of traditional knowledge, particularly highlighting the role of organic bioactives products. This study describes the synthesis and pharmacokinetic profiling of a series of organic compounds of pharmaceutical interest that were designed to act as potential bioactive agents. Synthesis strategies were optimized to improve reaction yields. Comprehensive spectroscopic analyses, including nuclear magnetic resonance analysis of protons and carbon-13 (¹H and ¹³C) and mass spectrometry, were employed to verify the molecular structures and evaluate the purity of the synthesized compounds. The synthesized products were then theoretically evaluated for their pharmacokinetics using standard drug-type tests. The results revealed that products were obtained in the best yields (65-82%) using our validated protocols of synthesis and characterized for their structure. For the theoretical study on their pharmaceuticals assessments, most of the compounds exhibited favorable pharmacokinetic profiles (that satisfied the key criteria of Lipinski, and the Connolly parameters (solubility and stability)), as well as demonstrating a good safety profile. This study highlights the importance of combining optimized synthesis methodologies with computational pharmacokinetic screening as an effective method for the initial design and evaluation of new molecules.
VL  - 14
IS  - 1
ER  -

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Author Information

Bienvenu Glinma

Chemistry Department, University of Abomey-Calavi (LaCOSNA/FAST/UAC), Abomey-Calavi, Benin;Chemistry Department, University of Abomey-Calavi (MOCL/FSS/UAC), Cotonou, Benin;School of Pharmacy, Catholic University of Leuven (LDRI/UCL), Brussels, Belgium

Contact Email

http://orcid.org/0000-0002-0487-4704
Sedami Medegan Fagla

Chemistry Department, University of Abomey-Calavi (MOCL/FSS/UAC), Cotonou, Benin

http://orcid.org/0009-0008-8943-0715
Hyacinthe Finagnon Agnimonhan

Chemistry Department, University of Abomey-Calavi (LaCOSNA/FAST/UAC), Abomey-Calavi, Benin

http://orcid.org/0000-0003-2704-4866
Benedicta Kpadonou-Kpoviessi

Chemistry Department, University of Abomey-Calavi (LaCOSNA/FAST/UAC), Abomey-Calavi, Benin

http://orcid.org/0009-0002-7260-456X
Eleonore Yayi

Chemistry Department, University of Abomey-Calavi (LaCOSNA/FAST/UAC), Abomey-Calavi, Benin
Joachim Gbenou

Chemistry Department, University of Abomey-Calavi (LaCOSNA/FAST/UAC), Abomey-Calavi, Benin
Jacques Poupaert

School of Pharmacy, Catholic University of Leuven (LDRI/UCL), Brussels, Belgium
Fernand Gbaguidi

Chemistry Department, University of Abomey-Calavi (MOCL/FSS/UAC), Cotonou, Benin

http://orcid.org/0000-0002-4899-0408
Salome Kpoviessi

Chemistry Department, University of Abomey-Calavi (LaCOSNA/FAST/UAC), Abomey-Calavi, Benin

http://orcid.org/0000-0002-9959-5061

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APA Style

Glinma, B., Fagla, S. M., Agnimonhan, H. F., Kpadonou-Kpoviessi, B., Yayi, E., et al. (2026). Synthesis and Pharmacokinetic Evaluation of Novel Bioactive Organic Compounds. American Journal of Chemical Engineering, 14(1), 1-7. https://doi.org/10.11648/j.ajche.20261401.11

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ACS Style

Glinma, B.; Fagla, S. M.; Agnimonhan, H. F.; Kpadonou-Kpoviessi, B.; Yayi, E., et al. Synthesis and Pharmacokinetic Evaluation of Novel Bioactive Organic Compounds. Am. J. Chem. Eng. 2026, 14(1), 1-7. doi: 10.11648/j.ajche.20261401.11

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AMA Style

Glinma B, Fagla SM, Agnimonhan HF, Kpadonou-Kpoviessi B, Yayi E, et al. Synthesis and Pharmacokinetic Evaluation of Novel Bioactive Organic Compounds. Am J Chem Eng. 2026;14(1):1-7. doi: 10.11648/j.ajche.20261401.11

Copy | Download

@article{10.11648/j.ajche.20261401.11,
  author = {Bienvenu Glinma and Sedami Medegan Fagla and Hyacinthe Finagnon Agnimonhan and Benedicta Kpadonou-Kpoviessi and Eleonore Yayi and Joachim Gbenou and Jacques Poupaert and Fernand Gbaguidi and Salome Kpoviessi},
  title = {Synthesis and Pharmacokinetic Evaluation of Novel Bioactive Organic Compounds},
  journal = {American Journal of Chemical Engineering},
  volume = {14},
  number = {1},
  pages = {1-7},
  doi = {10.11648/j.ajche.20261401.11},
  url = {https://doi.org/10.11648/j.ajche.20261401.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajche.20261401.11},
  abstract = {The integration of medicinal chemistry with modern computational and in silico approaches enables the scientific re-evaluation of traditional knowledge, particularly highlighting the role of organic bioactives products. This study describes the synthesis and pharmacokinetic profiling of a series of organic compounds of pharmaceutical interest that were designed to act as potential bioactive agents. Synthesis strategies were optimized to improve reaction yields. Comprehensive spectroscopic analyses, including nuclear magnetic resonance analysis of protons and carbon-13 (¹H and ¹³C) and mass spectrometry, were employed to verify the molecular structures and evaluate the purity of the synthesized compounds. The synthesized products were then theoretically evaluated for their pharmacokinetics using standard drug-type tests. The results revealed that products were obtained in the best yields (65-82%) using our validated protocols of synthesis and characterized for their structure. For the theoretical study on their pharmaceuticals assessments, most of the compounds exhibited favorable pharmacokinetic profiles (that satisfied the key criteria of Lipinski, and the Connolly parameters (solubility and stability)), as well as demonstrating a good safety profile. This study highlights the importance of combining optimized synthesis methodologies with computational pharmacokinetic screening as an effective method for the initial design and evaluation of new molecules.},
 year = {2026}
}

Copy | Download

TY  - JOUR
T1  - Synthesis and Pharmacokinetic Evaluation of Novel Bioactive Organic Compounds
AU  - Bienvenu Glinma
AU  - Sedami Medegan Fagla
AU  - Hyacinthe Finagnon Agnimonhan
AU  - Benedicta Kpadonou-Kpoviessi
AU  - Eleonore Yayi
AU  - Joachim Gbenou
AU  - Jacques Poupaert
AU  - Fernand Gbaguidi
AU  - Salome Kpoviessi
Y1  - 2026/01/26
PY  - 2026
N1  - https://doi.org/10.11648/j.ajche.20261401.11
DO  - 10.11648/j.ajche.20261401.11
T2  - American Journal of Chemical Engineering
JF  - American Journal of Chemical Engineering
JO  - American Journal of Chemical Engineering
SP  - 1
EP  - 7
PB  - Science Publishing Group
SN  - 2330-8613
UR  - https://doi.org/10.11648/j.ajche.20261401.11
AB  - The integration of medicinal chemistry with modern computational and in silico approaches enables the scientific re-evaluation of traditional knowledge, particularly highlighting the role of organic bioactives products. This study describes the synthesis and pharmacokinetic profiling of a series of organic compounds of pharmaceutical interest that were designed to act as potential bioactive agents. Synthesis strategies were optimized to improve reaction yields. Comprehensive spectroscopic analyses, including nuclear magnetic resonance analysis of protons and carbon-13 (¹H and ¹³C) and mass spectrometry, were employed to verify the molecular structures and evaluate the purity of the synthesized compounds. The synthesized products were then theoretically evaluated for their pharmacokinetics using standard drug-type tests. The results revealed that products were obtained in the best yields (65-82%) using our validated protocols of synthesis and characterized for their structure. For the theoretical study on their pharmaceuticals assessments, most of the compounds exhibited favorable pharmacokinetic profiles (that satisfied the key criteria of Lipinski, and the Connolly parameters (solubility and stability)), as well as demonstrating a good safety profile. This study highlights the importance of combining optimized synthesis methodologies with computational pharmacokinetic screening as an effective method for the initial design and evaluation of new molecules.
VL  - 14
IS  - 1
ER  -

Copy | Download