Development and Validation for RP-HPLC Method of Assay of Omeprazole Capsules Formulation
Mahmoud Mohamed Ali,
Eshtiag Abdalla Ibrahim,
Mohamed N. Abdalaziz
Issue:
Volume 6, Issue 1, January 2018
Pages:
1-6
Received:
10 August 2017
Accepted:
5 September 2017
Published:
9 January 2018
Abstract: Omeprazole is a potent proton pump inhibitor for the treatment of various acid-related gastrointestinal disorders. simple, selective and rapid reversed phase high performance liquid chromatographic (RP-HPLC) method for the analysis of Omeprazole has been developed and validated. The separation was achieved from HPLC column (ZORBAX, XDB, C-18 (150×4.6 mm, 5 micron) with a mobile phase consisting of HPLC grade acetonitrile and phosphate buffer solution (pH 7.4) in the ratio of (60:40 v/v) at a flow rate of 0.5 ml/min and runtime 10 min with UV detector at 302nm. The method was specific and it was observed that no interference with diluents. The proposed method was accurate with 100.95% recovery omeprazole and precise (% RSD of area of system precision, % RSD of assay of method precision were found to be 0.14% and 0.37% respectively). From the linearity study the correlation coefficient is found to be 0.9988, which indicated that the method was linear over 25% to 175% range. The method was found robust for possible changes. Therefore, this method can be used as a more convenient and efficient option for the analysis of Omeprazole to establish the quality of the drug substance during routine analysis with consistent and reproducible results.
Abstract: Omeprazole is a potent proton pump inhibitor for the treatment of various acid-related gastrointestinal disorders. simple, selective and rapid reversed phase high performance liquid chromatographic (RP-HPLC) method for the analysis of Omeprazole has been developed and validated. The separation was achieved from HPLC column (ZORBAX, XDB, C-18 (150×4...
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Study on the Determination Method of the Inclination of the Large Height Chute
Jia Lan,
Wang Dongxing,
Zhou Duo,
Liang Bing
Issue:
Volume 6, Issue 1, January 2018
Pages:
7-11
Received:
30 September 2017
Accepted:
25 October 2017
Published:
19 January 2018
Abstract: For a chute with a large elevation difference, it is important to choose the right inclination of chute, both to ensure the material will accelerate at a steady flow in the chute, and to meet the requirements of flow speed. In this situation the chute inclination cannot be determined according to conventional methods for a single factor, because in order to ensure the safety and environmental protection of the chute transportation, the chute inclination’s relationship to the moisture content of materials, the content of rock powder and a variety of other factors are considered. Through a theoretical analysis and experimental study, the results showed that the maximum water absorption in the moisture content, the water content and the inclination of the chute are proportional. Rock powder content and the relationship between the inclination tended to a logarithmic function relation curve. Put forward a formula for determining the chute inclination.
Abstract: For a chute with a large elevation difference, it is important to choose the right inclination of chute, both to ensure the material will accelerate at a steady flow in the chute, and to meet the requirements of flow speed. In this situation the chute inclination cannot be determined according to conventional methods for a single factor, because in...
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Mass Transfer Influence on Entropy Generation Fluctuation on Saturated Porous Channel Poiseuille Benard Flow
Mounir Bouabid,
Rahma Bouabda,
Mourad Magherbi
Issue:
Volume 6, Issue 1, January 2018
Pages:
12-18
Received:
27 December 2017
Accepted:
10 January 2018
Published:
16 April 2018
Abstract: This paper reports a transient state numerical investigation of irreversibility in a saturated porous channel, of an aspect ratio A= 5, under vertical thermal and mass gradients. The governing equations, using the Darcy-Brinkman formulation, have been solved numerically by using Control Volume Finite Element Method (CVFEM). Only two variables are taken into account, the Schmidt number and the floatability ratio. The other parameters values are fixed related to the Poiseuille–Benard flow (at zero mass gradients). Results reveal that the flow tends towards the steady state with different regimes, which depends on both the Schmidt number and the buoyancy ratio.
Abstract: This paper reports a transient state numerical investigation of irreversibility in a saturated porous channel, of an aspect ratio A= 5, under vertical thermal and mass gradients. The governing equations, using the Darcy-Brinkman formulation, have been solved numerically by using Control Volume Finite Element Method (CVFEM). Only two variables are t...
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